@shanselman pointed out an interesting blog post titled "Building a web app the Microsoft way" where the author Jeremy Baines dose a good job of giving the facts that he and his team found while developing ‘Meet with Approval’. I could not find the case study that was mentioned but that is because the case study site sucks, I will try to find it internally and find the external link.
I know that I have tainted opinion but I don't see why more people\companies\startups don't evaluate the MS stack. From all of the comments only one that I saw was accurate and that is that Windows hosting is quite abit more expensive than LAMP hosting but I think that price will be coming down with the new support we have in Windows Server 2008 for hosters. I also think that a company looking at long term success and would want to look at the cost of self hosting, there are a lot of reasons that Windows for self hosting can be more cost effective but the big one for me is support.
Disclaimer The opinions expressed herein are my own personal opinions and do not represent my employer's view in anyway.